Bone Marrow Failure disorders

Bone marrow failure occurs in individuals who produce an insufficient amount of red blood cells, white blood cells or platelets.

Causes

Bone marrow failure in both children and adults can be either inherited or acquired. Inherited bone marrow failure is often the cause in young children, while older children and adults may acquire the disease later in life.
The most common cause of acquired bone marrow failure is aplastic anaemia.

Myelodysplastic syndromes (MDS) is a form of blood cancer found within the bone marrow in which the body no longer produces enough healthy, normal blood cells. MDS is a frequently unrecognized and rare group of bone marrow failure disorders.

Signs and symptoms

The most common signs and symptoms of bone marrow failure are chronic fatigue, shortness of breath, bleeding, bruising and recurrent infections.